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Stop taking these medications if you want to save your memory! (dementia risk)

Ouadie RhabbouronMay 9, 2026

One of the main groups of drugs that might lead to dementia are those that block or stop acetylcholine. This is a really important chemical in your brain that helps with learning and memory. Some common medicines in this group include:

  • Antihistamines, like Benadryl.
  • Certain antidepressants.
  • Medicines for an overactive bladder.

If you take these kinds of medicines for a long time, especially if you’re older and already at risk for brain diseases, you might have a higher chance of memory problems. It’s because these drugs mess with that important acetylcholine.

Another group of drugs to be careful with are benzodiazepines. These are often given for anxiety, trouble sleeping, and seizures. Medicines like these can slow down your central nervous system. Taking them for a long time has also been linked to a higher risk of dementia.

Even some common medicines for heartburn and indigestion, called proton pump inhibitors, might play a role in memory issues if you take them all the time. Research suggests these drugs can change the good bacteria in your gut and how your body takes in nutrients, which can indirectly affect your brain health.

The Problem with Too Many Pills: Polypharmacy

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